The available database comprises research projects in Fisheries, Aquaculture, Seafood Processing and Marine Biotechnology active in the time period 2003-2022.
BlueBio is an ERA-NET COFUND created to directly identify new and improve existing ways of bringing bio-based products and services to the market and find new ways of creating value from in the blue bioeconomy.

More information on the BlueBio project and participating funding organizations is available on the BlueBio website: www.bluebioeconomy.eu

Last Update: 2024/06/19

NA
Aquaculture
Exosomes from salmon (Salmo salar) leukocytes - composition, functions, biogenesis and immunodiagnostic potential
National Programme
National
Dimitar Borisov Iliev
NA
UiT - The Arctic University of Norway (Norway)
NA
2014
2018
€ 406,700
https://prosjektbanken.forskningsradet.no/en/project/FORISS/230735?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=0&Organisasjon.5=Norges+fiskerih%C3%B8gskole
Due to their involvement in pathological conditions and their potential to be used as diagnostic and therapeutic tools, exosomes have been studied intensely in mammalian experimental systems. In contrast, knowledge about exosome composition, functions and biogenesis in lower vertebrates is scant. In the current project, we are studying exosomes released from primary salmon leukocytes. Secretion of exosomes from head kidney leukocytes is up regulated following stimulation with toll-like receptor ligands, most robustly following stimulation with CpG oligonucleotides (TLR9/21 ligand). Biochemical analyses indicate that protein composition of salmon exosomes is very similar to that of their mammalian counterparts. Salmon exosomes contain high levels of RNA - including mRNA and miRNA. The proteomic analysis indicated that these vesicles might be involved in cross-presentation. In addition to the high levels of MHC-I and II molecules, salmon leukocyte-derived exosomes are also enriched in proteins involved in processing and loading exogenous antigens onto MHC-I complexes.
Fish biology; Salmon; Genetic; Fish;
Not associated to marine areas
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