Acronym NA
Category
Aquaculture
Title Intestinal primary barriers Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Kristina Sundell Coordinator email kristina.sundell@bioenv.gu.se
Coordinator institution
UGOT - University of Gothenburg (Sweden)
Institutions involved
NA
Start year 2007 End year 2010 Funding (€) € 33,300 Website NA Summary The gastrointestinal tract of fish is vital for food digestion, nutrient uptake and regulation of ion and water uptake. There is a great challenge for the intestinal epithelium to act as a barrier and selectively absorb ingredients while preventing passage of hazardous substances like invading pathogens. The intestinal barrier consists of physiological and immunological parts, communicating with each other in a complex pattern. These parts can be affected by endogenous substances, hormones and cytokines, as well as by exogenous factors like pathogens, feed ingredients and husbandry conditions. Disturbed barrier functions may lead to increased disease susceptibility. The overall aim of the present project is to increase the understanding of the physiological and immune barriers of the intestinal epithelium. Special emphasis will be placed on host-pathogen interactions, endocrine signals and the crosstalk between the physiological and immunological systems. This will be achieved through experiments designed to meet the following specific goals: (1) To increase our knowledge of the physiological nature of the fish intestinal primary barrier; (2) To investigate the innate immune responses to pathogens in the intestinal epithelium; (3) To understand the cross-talk between the physiological and immunological parts of the intestinal barrier; (4) To elucidate environmental factors evoking primary stress responses and how these affect physiological and immunological barrier properties.
Keywords
Fish biology;
Fish;
Parasite;
Animal welfare;
Marine Region
76
Not associated to marine areas
0
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