Acronym PRV PROTect
Category
Aquaculture
Title Targeting piscine orthoreovirus (PRV) infection in Norwegian Atlantic salmon aquaculture Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Vidar Aspehaug Coordinator email NA
Coordinator institution
NA
Institutions involved
NA - Marine Harvest Norway AS (Norway) ,
NVH - Norwegian School of Veterinary Science (Norway) ,
NVI - Norwegian Veterinary Institute (Norway) ,
Start year 2014 End year 2017 Funding (€) € 610,000 Website https://prosjektbanken.forskningsradet.no/en/project/FORISS/235788?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=270&ProgAkt.3=HAVBRUK2-Stort+program+for+havbruksforskning&source=FORISS&projectId=233865 Summary Norwegian salmon aquaculture have in the last two decades experienced an increasing number of outbreaks from heart- and skeletal muscle inflammation (HSMI), a disease associated with the piscine orthoreovirus (PRV). PRV is ubiquitous in farmed and wild salmon globally, and a better understanding of the effects of this virus on fish health is needed. The virus also appears to be present in fish with no clinical signs of disease. This project aim to increase the understanding of how to protect the fish from HSMI, and to what extent the spread of PRV can be limited and controlled by targeted strategies.
PatoGen, Marine Harvest, the Norwegian Veterinary Institute (NVI) and the Norwegian School of Veterinary Science (NVH) have joined forces in this project with the aim for better control and increased understanding of the role of PRV for disease development.
Patogen Analyse have previously performed extensive mapping of PRV in fish farms and recently developed phylogenetic tools to screen for viral variants and thereby uncover the source and spread of the virus. In this project we will map the infection routes more closely, aiming to limit viral spread and study the link between the virus and the health status of the fish.
Recent studies on PRV pathogenesis have been performed by the researchers from NVI and NVH involved in this project, and have revealed that the virus infects red blood cells prior to the infection of the myocytes of the heart. A PRV infection in blood cells may potentially have consequences for the health state and production state of the salmon. It is natural to hypothesize that the primary properties of the fish blood cells, including oxygen transport and oxygen delivery to muscle tissue, may be affected and that this can reduce fitness and robustness of the fish. The inflammatory injury to heart and muscle observed for HSMI may also be oxygen deprivation, and this will be studied alongside other possible consequences of a PRV infection.
We wish to develop better tools and strategies to monitor PRV infection, spread and effects on the robustness and health state of the fish. This may be of importance for a more robust and sustainable aquaculture.
Keywords
Salmon;
Fish;
Disease;
Fish health;
Marine Region
76
Not associated to marine areas
0
Marine Region Map
