Acronym NA
Category
Aquaculture
Title Gene editing for elucidating gene function and refining genomic selection for CMS resistance in Atlantic salmon Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Nicholas Robinson Coordinator email NA
Coordinator institution
NOFIMA - Norwegian Institute of Food, Fisheries and Aquaculture Research (Norway)
Institutions involved
FNI - Fridtjof Nansen Institute (Norway) ,
Start year 2019 End year 2025 Funding (€) € 1,009,030 Website https://prosjektbanken.forskningsradet.no/project/FORISS/294504?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=450&Departement=Ukjent&Departement=Landbruks-+og+matdepartementet Summary Gene editing technologies are developing at a faster pace than ever and open up new opportunities for breeding to improve production efficiency and disease resistance. Cardiomyopathy syndrome (CMS) is an important disease for the aquaculture industry in Norway because of economic loss and welfare implications. To mitigate the impact of the disease selective breeding is practiced, however, it is challenged by veterinary restrictions and expensive challenge tests. Genomic studies for the trait have located quantitative trait loci (QTL) with strong signal on chromosome 27. The use of state-of-the-art gene editing technologies for improvement of CSM resistance is likely to be highly beneficial in this case. The project will identify potential genes and causative mutations affecting CMS resistance, and evaluates their function by in-vitro cardiomyocyte cell culture. Further, the proposal will develop breeding strategies that effectively employ gene editing to develop CMS resistant salmon, and a special scheme to deliver edited genes to multipliers tiers, which produces fingerlings that are grown for production, will be designed. The ethical, social and legal implications of developing CMS resistant salmon using gene editing will be determined. Dynamic RRI (responsible research and innovation) processes, in particular active stakeholder involvement, are used to promote an active attitude towards RRI in gene editing. The project will create a knowledge base and example for the industry regarding disease management through state-of-the-art gene editing, this will greatly improve the bioeconomy and welfare of Atlantic salmon production.
Keywords
Fish health;
Disease;
Genetic;
Engineering;
Fish;
Salmon;
Marine Region
76
Not associated to marine areas
0
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