Acronym NA
Category
Marine Biotechnology
Title Discovering novel functions of carbohydrate-active enzymes to unravel novel mechanisms of bacterial virulence Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Gustav Vaaje-Kolstad Coordinator email NA
Coordinator institution
NMBU - Norwegian University of Life Sciences (Norway)
Institutions involved
NA - AquaGen AS (Norway) ,
NA - EWOS Innovation AS (Norway) ,
IMR - Institute of Marine Research (Norway) ,
NTNU - Norwegian University of Science and Technology (Norway) ,
UiT - The Arctic University of Norway (Norway) ,
Start year 2016 End year 2021 Funding (€) € 903,225 Website https://prosjektbanken.forskningsradet.no/en/project/FORISS/249865?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=30&ProgAkt.3=FRIBIO2-FRIPRO+forskerprosjekt%2C+biologi Summary In the present project we will focus on the complex machinery used by disease causing bacteria to attach and invade the host. This machinery contains proteins that aid the bacterium in penetrating the first line of defense of the fish, represented by the immunoactive skin mucus barrier. Little is known about this complex mechanism. In order to improve our understanding of the adhesion and infection process we will use an interdisciplinary approach. Firstly, we will monitor all genes in the bacterial genome during the infection process and determine which that are activated and used for adhesion and invasion. The most important proteins represented by these genes will be characterized by state-of-the-art mass spectroscopy and other advanced biochemical methods. Further, we will remove the infection-related genes from the disease causing bacteria and investigate how this influences the ability of the bacteria to infect the host. In parallel to this, we will also study specific proteins that already have been identified as involved in infection, but not studied in detail. The results emerging from this project will yield new knowledge in the battle against disease causing bacteria in fish. This knowledge is also relevant for other pathogen-host systems where similar mechanism of infections are employed, e.g. infectious bacteria targeting humans.
Keywords
Salmon;
Disease;
Fish health;
Genomic;
Bacteria;
Engineering;
Fish;
Marine Region
76
Not associated to marine areas
0
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