Acronym ImmunDNA
Category
Aquaculture
Title DNA vaccines against viral diseases in salmon – immune mechanisms and new vaccine concepts Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Ingvill Jensen Coordinator email ingvill.jensen@uit.no
Coordinator institution
UiT - The Arctic University of Norway (Norway)
Institutions involved
NA - Cermaq Norway AS (Norway) ,
NA - Grieg Seafood ASA
(Norway) ,
NA - SalMar ASA (Norway) ,
Start year 2022 End year 2025 Funding (€) € 1,615,600 Website https://www.fhf.no/prosjekter/prosjektbasen/901759/ Summary Viral diseases cause major losses in the Norwegian farming industry and are one of the biggest challenges for the industry. For some viral diseases there are commercial vaccines, but these have limited effectiveness. For other viral diseases, there are currently no commercial vaccines. New and more effective virus vaccines will contribute to improved fish welfare and economic growth. Previous research has shown that DNA vaccines can be very effective in salmon, but the effectiveness is not equally good against all viruses. It has also been shown that DNA vaccines that consist only of antigens can have limited effectiveness and adjuvants are often needed to increase the effect and provide a better immune response. The ImmunDNA project will test the effect of several different molecular adjuvants in DNA vaccines against salmon viruses. In addition, new technology that makes it possible to create one vaccine construct for several viruses will be optimized for salmon and used in combination with molecular adjuvants.
Main objective:
To improve current virus vaccines for salmon by developing a new generation of DNA vaccines that combine antigens from different viruses and new adjuvants.
Sub-goals:
1) To make vaccine constructs with various adjuvants and after testing select the most potent ones for further testing in combination with virus antigens.
2) To make a vaccine construct for several viruses, which can be injected as a single dose into the fish.
3) To identify which cells at the vaccination site are important for providing an effective and protective immune response.
4) To develop and test new measurement methods for immune parameters related to protection after DNA vaccination.
Keywords
Fish health;
Salmon;
Genetic;
Vaccines development;
Disease;
Fish;
Marine Region
76
Not associated to marine areas
0
Marine Region Map
