Acronym NA
Category
Aquaculture
Title Developing fish-food safety control measures against antimicrobial resistance by reprogramming metabolism in farmed fish Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Hetron Mweemba Munangandu Coordinator email NA
Coordinator institution
NMBU - Norwegian University of Life Sciences (Norway)
Institutions involved
NA
Start year 2021 End year 2023 Funding (€) € 500,000 Website https://prosjektbanken.forskningsradet.no/en/project/FORISS/320692?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=30&ProgAkt.3=HAVBRUK2-Stort+program+for+havbruksforskning Summary Antimicrobial resistance has increased to be one of the biggest global health threats. Many AMR bacteria enter the food chain from farmed animals and a control strategy is to reduce transmission of AMR from food to humans. Aquaculture is a leading source of food production, with fast growth accounting for 1/3 of global food production. China accounts for 61% of global aquaculture production, and Norway is the largest producer of salmon globally. Increased disease incidence in farming systems has led to increase in antibiotics use. Consequently, AMR-genes are detected in aquatic environments, farmed fish, growth promoters, processed fish, and ready-to-eat fish food, with an increased risk of human exposure. This project aims to develop an approach for control of AMR in fish-food. Methods include high throughput sequencing technology (metagenomics analyses) to profile AMR bacteria in the salmon production chain in Norway and tilapia in China. The aim is to determine the relative abundance AMR-genes in fish samples and to identify stages in the fish-food production chain prone to contamination by AMR-bacteria. Risk assessment of AMR-gene transmission to humans through fish food will be included aiming to reduce the risk of human exposure. Methods have been developed using metabolism-based reversal of antibiotic resistant bacteria to become sensitivity based on identifying different metabolism pathways. Metabolites repressed in antibiotic resistant bacteria can be by gas chromatography and Liquid Chromatography and these metabolites can be used to reprogram the metabolome of antibiotic resistant bacteria rendering them sensitive of antibiotic treatment. Metagenomics is used to profile metabolites causing antibiotic-resistance and such metabolites are used for metabolome reprogramming against AMR with feed nutrient metabolites in in vitro and in vivo experiments. Methods developed will contribute to reduce the transmission of AMR-genes through fish foods to humans.
Keywords
Metagenomic;
Engineering;
Food safety;
Bacteria;
Salmon;
Genetic;
Fish products;
Fish;
Antibacterial;
Marine Region
76
Not associated to marine areas
0
Marine Region Map
