Acronym NA
Category
Marine Biotechnology
Title Oral delivery of encapsulated viral antigens to Atlantic salmon Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Simon Wadsworth Coordinator email simon.wadsworth@ewos.com
Coordinator institution
NA
Institutions involved
NA
Start year 2010 End year 2014 Funding (€) € 156,700 Website https://prosjektbanken.forskningsradet.no/en/project/FORISS/202089?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=480&ProgAkt.3=NAERINGSPH-N%C3%A6rings-phd Summary A range of viral pathogens currently present a significant challenge to Atlantic salmon operations globally. Injection vaccines are used commercially against a number of virus, but these are not available for small fish and protection may decline some months after seawater transfer. The development of effective oral vaccines would allow small fish to be protected as well as providing the ability to boost the immune system of larger fish. This could significantly increase operational flexibility as well as reduce losses from viral pathogens. Oral vaccines have not been successful in aquaculture operations. They may be denatured during feed production process as well as the digestive system within the fish. Uptake across the gut may be limited and the large quantities of vaccine required have made them uneconomic. The following programme will assess oral delivery systems that can protect the antigens against the digestive process of fish. These delivery systems will be deployed at optimal phases of the feed production process. Alginate and mesoporous silica will be used to encapsulate viral antigens of Infectious Salmon Anemia (ISA) and Infectious Pancreatic Necrosis (IPN) Virus. In vitro assays will assess survival of encapsulated antigens through adverse temperatures, pH and enzymatic activity. Immune assessments will determine antigen uptake in vivo and compare oral delivery with anal and oral intubation. Protection will be determined under controlled challenge.
Keywords
Fish;
Disease;
Technology;
Fish health;
Salmon;
Fish biology;
Marine Region
76
Not associated to marine areas
0
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