Acronym NucNanoFish
Category
Aquaculture
Title Nucleic NanoVaccines for Fish Programme International Cooperation
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National-European Coordinator NA Coordinator email NA
Coordinator institution
NA
Institutions involved
NA - Delphi Genetics (Belgium) ,
INRAE - National Research Institute for Agriculture, Food and Environment (France) ,
NMBU - Norwegian University of Life Sciences (Norway) ,
UOA - University of Aberdeen (United Kingdom) ,
Start year 2021 End year 2024 Funding (€) € 316,900 Website https://www.era-learn.eu/network-information/networks/icrad/1st-icrad-call-2019/nucleic-nanovaccines-for-fish Summary Farmed fish are hit by a number of infectious diseases, and viral infections lead to compromised health and welfare and result in economic losses. Few vaccines are available against viral diseases and therefore new vaccines are needed to prevent against disease. Different vaccines have been developed, some suitable for larger fish but not for pre-injection size. mRNA vaccines represent a new technology, tested to a limited extent in fish, in contrast to mammals where they induce strong responses and good protection, These vaccines are fast to produce and safer than standard DNA vaccines. This project will establish a platform based on biodegradable nanoparticles for intra-muscular or by oral/bath delivery to different size fish, focusing on viral diseases affecting farmed fish species in Europe. Different disease entities will be studied and we will test DNA/mRNA vaccines using lipo-nano-particles (LNP). LNPs are based on Poly-Lactic/Glycolic Acid cores surrounded with a lipid corona. This will allow efficient uptake over mucosal surfaces and induction of protective immune responses. The project includes six partners with complementary expertise related to delivery of mRNA-LNP vaccines and four groups covering fish vaccinology and immunology. Three fish species will be studied, rainbow trout, common carp and Atlantic salmon, and altogether four viral diseases. The overarching aim is to develop novel, safe vaccines that will protect fish against defined viral diseases and increase health, welfare and profitability of the industry in Europe.
Keywords
Fish health;
Genetic;
Disease;
Trout;
Fish;
Carp;
Salmon;
Vaccines development;
Marine Region
76
Not associated to marine areas
0
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