Acronym NA
Category
Aquaculture
Title Physiology, pharmacology and immunology of ion channels in Atlantic salmon and the salmon louse, Lepeophtheirus salmonis Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Tor Einar Horsberg Coordinator email NA
Coordinator institution
NMBU - Norwegian University of Life Sciences (Norway)
Institutions involved
NA
Start year 2021 End year 2025 Funding (€) € 1,200,000 Website https://prosjektbanken.forskningsradet.no/project/FORISS/319756?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=30&TemaEmne.1=LTP2%20Hav Summary Ion-channels are essential cellular mechanisms present in all living organisms. A major function is regulation of ion flow across cell membranes in excitable cells like neurons and muscle cells. Ion-channels are targets for more than 700 drugs used in human- and veterinary medicine against a wide variety of conditions such as elevated blood pressure, anxiety, and parasites. The anti-sealice agents azamethiphos, deltamethrin and emamectin benzoate all act – by different mechanisms - on ion-channels. Although not widely used as vaccine targets, ion channels could also be target proteins for recombinant vaccines. In this four-year project, the various ion-channels present in both Atlantic salmon and the salmon louse will be sought identified through a systematic approach. The genomes of Atlantic salmon and salmon lice are fully sequenced, and the tools for a thorough, comparative bioinformatics analysis of these important proteins in both species are now available. The overall aim of the project is to identify the ion-channels present in the Atlantic salmon and the salmon louse, and to evaluate whether some of these channels in the parasite are potential targets for chemical or immunological control, with minimal effect on the fish. This will be done by 1) Identification and comparison of ion-channels in Atlantic salmon and salmon lice with bioinformatics tools 2) Evaluation of selected ion-channels as possible chemical targets, based on toxicity tests with model substances and RNA-interference studies, and after expression in Xenopus oocytes and tests with model substances 3) Evaluation of selected ion-channels as possible immunological targets, based on bioinformatics evaluation of immunological properties and immunization experiments The project will be a truly multidisciplinary project requiring expertise in electrophysiology, parasitology, veterinary sciences, bioinformatics, molecular biology, and immunology.
Keywords
Genomic sequencing;
Genetic;
Parasite;
Salmon;
Vaccines development;
Fish;
Marine Region
76
Not associated to marine areas
0
Marine Region Map
