Acronym SALMOSTERILE
Category
Aquaculture
Title Sterile salmon by targeting factors involved in germ cell survival: novel vaccination strategies for sustainable fish farming (Sketch 40) Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Anna Troedsson-Wargelius Coordinator email anna.wargelius@imr.no
Coordinator institution
IMR - Institute of Marine Research (Norway)
Institutions involved
UiB - University of Bergen (Norway) ,
Start year 2012 End year 2018 Funding (€) € 4,954,800 Website https://prosjektbanken.forskningsradet.no/en/project/FORISS/221648?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=60&TemaEmne.2=Mat+-+Bl%C3%A5gr%C3%B8nn&source=FORISS&projectId=290318 Summary In this project we attempt to make vaccines directed against proteins controlling the survival of early germ cells (primordial germ cells, PGCs) or gametes just before puberty. Experiments with zebrafish have shown that germ cells requires survival signals, and at the disappearance of these signals, the cells are arrested in development and undergo programmed cell death (apoptosis). The main concept behind the brood fish vaccination approach is that a sterility vaccine in will inactivate sex cell survival proteins in the developing salmon larva, and thereby forcing the PGCs into apoptosis. The gonads of the developing fish will be devoid of gametes, and unable to produce eggs or sperm the fish will be sterile. Such a vaccine may be given to the mother prior to egg maturation and spawning, as maternal antibodies will be transferred to the egg. Such a technology will be very cost-efficient, as vaccination of one female lead to sterility in more than 15 000 offspring.
Keywords
Fish health;
Vaccines development;
Salmon;
Disease;
Fish;
Genetic;
Fish reproduction;
Marine Region
76
Not associated to marine areas
0
Marine Region Map
