Acronym SYBIATT
Category
Aquaculture
Title Synthetic biology and rational virus attenuation - a study on Salmonid pancreas disease virus Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Aderito Luis Monjane Coordinator email aderito-luis.monjane@vetinst.no
Coordinator institution
NVI - Norwegian Veterinary Institute (Norway)
Institutions involved
INRA - French National Institute for Agricultural Research (France) ,
NSC - National Safety Council (United States of America) ,
NA - Oslo University Hospital (Norway) ,
UCT - University of Cape Town (South Africa) ,
Start year 2017 End year 2020 Funding (€) € 221,297 Website https://prosjektbanken.forskningsradet.no/en/project/FORISS/267978?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=180&ProgAkt.3=HAVBRUK2-Stort%20program%20for%20havbruksforskning Summary All life forms are encoded by their specific genetic sequence and, importantly, within an organisms' genetic sequence are the instructions for all aspects of its life cycle. In the case of viruses, for example, these instructions may dictate which organisms the virus can parasitize, and how successfully the virus can replicate in those organisms. Because such instructions are so crucial to survival, those organisms - among a group of related ones - with instructions different from the 'hard-wired' ones may reproduce poorly, or may cease to reproduce altogether. The primary goal of our study is to search for the presence of such hard-wired instructions in the genetic sequence of a virus that routinely upsets the health of salmon, as well as the economic gains of the Norwegian aquaculture industry. With such knowledge we intend then to sabotage these hard-wired instructions in a way that will lead to a controlled reduction in that viruses' ability to cause severe disease in salmon. The usefulness of the weakened state of such a virus, much like the usefulness of a virus vaccine in humans, is that it will allow us to understand in clearer detail which instructions within the virus' genetic sequence make it so pathogenic to salmon, but also which cascade of genetic events will occur within the salmon itself as it fights off an infection from this weakened virus. Collectively, this information will give us valuable clues as to how vaccines against virus infections in salmon should be designed so that we can safeguard the health of salmon as well as that of the aquaculture industry.
Keywords
Fish;
Salmon;
Disease;
Genetic;
Parasite;
Marine Region
76
Not associated to marine areas
0
Marine Region Map
