Acronym VaccInAqua
Category
Marine Biotechnology
Title Indo-Norwegian platform on fish and shellfish vaccine development Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Roy A. Dalmo Coordinator email roy.dalmo@uit.no
Coordinator institution
UiT-NFH - The Arctic University of Norway; Norwegian College of Fishery Science (Norway)
Institutions involved
NA - Not available (India) ,
Start year 2008 End year 2013 Funding (€) € 5,317,382 Website https://prosjektbanken.forskningsradet.no/project/FORISS/183204?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=180&Departement=Fiskeri-+og+kystdepartementet&source=FORISS&projectId=199806 Summary Infectious diseases have a significant impact on the sustainability of the aquaculture industry, that being in finfish or shellfish/shrimp production environments. The subsequent use of antibiotics, drugs, and chemical disinfectants cause concern at all levels. The successful vaccines for salmon farming was developed with an element of trial and error and attempts to extend the experience to other fish species and pathogens have not been similarly successful. This shows there is need for improved understanding of functional and molecular aspects of fish immune mechanisms. This includes not only development of efficacious vaccines, but also the use molecular tools for monitoring the status of the immune system. Immunoprophylaxis in shrimp farming poses specific challenge since invertebrates cannot be vaccinated by traditional means. Recent findings indicate however that priming of innate mechanisms can lead to increased disease resistance in invertebrates. A further aquaculture development, a creation of a knowledge vaccine platform aiming to develop prophylactic measures to Indian major carps and seabass, Atlantic cod and halibut, Atlantic salmon, and shrimp is needed. Yet, no efficient vaccines against many pathogenic bacteria and viruses are available. A likely outcome of this project will be an achievement of efficient strategies to increase disease resistance in Indian and Norwegian aquacultured fish and shellfish. The work in this project has been structured into 5 workpackages (WPs), with a great deal of interaction between them. Vaccines against bacterial diseases will be covered in WP1, while different approaches of vaccination against viral diseases are addressed in WP2. WP3 covers antigens and delivery methods while we focus on in vitro methods used for profiling immune responses and in vivo challenge methods in WP4. WP5 covers training and exchange of personnel between partners.
Goals:
WP1: (1) Identify protective and conserved antigens of bacterial pathogens; (2) Clone, express and purify recombinant antigens; (3) Develop vaccines based on novel antigens, sequences and peptides. WP2: (1) Develop safe, replicating vaccines against IPNV and NNV; (2) Develop effective vaccines against WSSV in shrimp. WP3: Establish methods for rational design of vaccines against extra- and intracellular pathogens. WP4: (1) Develop immune response markers to assess the effects of vaccination and immunostimulation in cod, L. rohita and shrimp P. monodon; (2) Characterize humoral and cellular immune responses following infection with intra- and extracellular pathogens; (3) Characterize humoral and cellular responses following vaccination. WP5: To develop optimal training activities.
Keywords
Vaccines development;
Crustacean;
Cod;
Shrimp;
Disease;
Carp;
Fish;
Shellfish;
Marine Region
41
Norwegian Sea (27.IIa)
1
Marine Region Map
