Acronym NA
Category
Aquaculture
Title Toxicological mechanisms of non-dioxinlike persistent organic pollutants: tools for risk evaluation Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Henrik S. Huitfeldt Coordinator email henrik.huitfeldt@medisin.uio.no
Coordinator institution
UiO - University of Oslo (Norway)
Institutions involved
NA
Start year 2006 End year 2010 Funding (€) € 352,300 Website https://prosjektbanken.forskningsradet.no/project/FORISS/173201?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=120&Fag.3=N%C3%A6ringsmiddelteknologi Summary Norway is a major producer of farmed fish, and produces about 650 000 ton yearly. 95% of this is exported. Recently, the levels of persistent organic pollutants (POP) in farmed salmon has raised concerns. Although levels of dioxins and dioxin-like PCBs in Norwegian farmed salmon are well below EU-regulated thresholds, fat fish is a main source of these pollutants. WHO and EU recommend that dioxin and PCB levels in EU is lowered. Thus, the application of techniques to reduce POP levels in farmed fish feed will be welcomed and may represent a marketing advantage. Strict thresholds have been introduced for dioxins and dioxin-like PCBs, but not for the large group of non-dioxinlike PCBs or brominated flame retardants. From experimental investigation we know that these substances are carcinogenic and have deleterious effects on mental development. Some cohort studies from US and EU indicate that present levels of non-dioxinlike PCBs in EU and US populations are associated with neurotoxic effects. Our lack of knowledge of the molecular targets and mechanisms of these pollutants has made it impossible to define thresholds for complex mixtures (such as PCBs) based on animal experiments. This project aims at identification of the toxicological mechanisms of non-dioxinlike PCBs, and to evaluate if this approach can be used to create models of risk evaluation for non-dioxinlike PCBs. PCB153 will be used as a prototype, non-dioxinlike PCB. Primary rat hepatocytes will be exposed, and effects on proliferation, cell death and differentiation examined. Microarray techniques will be used to examine alterations in gene expression profiles. Alterations in membrane flow and intracellular signalling will be explored, and cell cycle progression will be investigated.
Keywords
Fish;
Toxic substances;
Food safety;
Salmon;
Marine Region
76
Not associated to marine areas
0
Marine Region Map
