Acronym NA
Category
Aquaculture
Title Translating the cod genome for aquaculture Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Kjetill Sigurd Jakobsen Coordinator email k.s.jakobsen@ibv.uio.no
Coordinator institution
UiO - University of Oslo (Norway)
Institutions involved
NA
Start year 2010 End year 2016 Funding (€) € 587,100 Website https://prosjektbanken.forskningsradet.no/project/FORISS/199806?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=300&ProgAkt.3=HAVBRUK2-Stort+program+for+havbruksforskning Summary We have completed a first - full genome - reference sequence of Atlantic cod (Gadus morhua) that will become publicly available within the next 6 months. In order to exploit this genome providing explicit benefit to the Norwegian community, we propose to take the cod genome sequence to the next level and translate this sequence into genomic tools for cod aquaculture. First, we will improve the cod reference sequence by refined bioinformatic analyses - including annotation and taking the heterozygosity int o account, and by constructing superscaffolds using existing BAC end sequence information. An extended annotation will improve the biological relevance of the genome, making it a more useful tool for cod aquaculture. Second, using this improved version of the genome, we will re-sequence and scan the genomes of multiple individuals of cod, characterizing genome-wide functional genomic variation. We will focus on traits important for cod aquaculture; among others, age at maturity, growth rates and disease r esistance. Third, our analysis of the cod reference genome has revealed that cod lack MHC class II genes. So far, cod is the only known vertebrate that lacks this important set of genes. This discovery may have profound implications for the development of vaccines and medications that are important in cod aquaculture. We aim to fully characterize the unique MHC system in cod, which will simultaneously stimulate the targeted development of vaccines preventing bouts of disease in cod aquaculture.
Keywords
Genomic sequencing;
Fish;
Cod;
Genetic;
Marine Region
76
Not associated to marine areas
0
Marine Region Map
