Acronym dCod 1.0
Category
Fisheries
Title dCod 1.0: Decoding systems toxicology of atlantic cod Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Anders Goksøyr Coordinator email NA
Coordinator institution
UiB - University of Bergen (Norway)
Institutions involved
NA
Start year 2016 End year 2021 Funding (€) € 4,000,000 Website https://prosjektbanken.forskningsradet.no/en/project/FORISS/248840?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=120&ProgAkt.3=BIOTEK2021-Bioteknologi+for+verdiskaping&source=EU&projectId=212879 Summary "The goal of the dCod-project is to combine the competencies in environmental toxicology, biology, bioinformatics and mathematics across the traditional department boundaries, to create a deeper understanding of cods' adaptations and reactions to stressors in the environment.
It is the aim of systems toxicology to integrate large datasets from environmental genomics (transcriptomics, proteomics, metabolomics) into meaningful representations of the toxic response, by using computational methods to detect enriched pathways, networks and interactions, and ultimately to develop mathematical models that can be used to predict adverse outcomes of specific exposures and mixtures. Phenotypic anchoring represents a process of determining the relationship between a particular toxicogenomic expression profile and the pathological or physiological phenotype of the organism for a particular exposure or dose and at a particular time. Studies performed in our group with Atlantic cod indicate that several environmental contaminants display effects related to lipid metabolism and other pathways connected with energy storage and generation. Hence, a phenotypic result of such effects may be reflected in growth rates of individual fish, or biomass of cod populations. Such effects, although subtle at the individual level, may have important economic effects if transformed into effects on biomass or recruitment in harvested fish stocks. The bold and ambitious aim of the dCod project is to generate sufficient insight into the systems biology of Atlantic cod to be able to model effects of contaminants on growth rates and reproduction."
Keywords
Cod;
Fish reproduction;
Genetic;
Genomic sequencing;
Fish biology;
Fish;
Impacts;
Toxic substances;
Marine Region
76
Not associated to marine areas
0
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