Acronym NA
Category
Fisheries
Title Regulation of oxidative stress specific gene expression in tumour tissue in flounder (Platichthys flesus) Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Joachim Sturve Coordinator email joachim.sturve@zool.gu.se
Coordinator institution
UGOT - University of Gothenburg (Sweden)
Institutions involved
NA
Start year 2008 End year 2008 Funding (€) € NA Website NA Summary Despite increasingly strict controls on the use of toxic, bioaccumulative and persistent chemicals, the aquatic environment continues to be the major sink for pollutants, and many rivers and estuaries are still severely contaminated. Several chemicals present in the environment can lead to the formation of tumours. A characteristic of several forms of tumours is altered expression of enzymes involved in the defence against reactive oxygen species or oxidative stress. The aim of the proposed project is to investigate up or down regulation of oxidative stress related parameters in flounder (Platichthys flesus) tumours of different stages. The objective is to identify possible biomarkers for tumours and tumour formation in flounder. An additional aim is to investigate possible roles of antioxidant enzymes in carcinogenesis. The proposed project has three specific objectives: (1) To investigate tumour prevalence and tumour forms in tissues from flounder. It is of importance for the project to determine form and stage of the investigated tumours; (2) To compare gene expression in tumour and non-tumour cells from the same tissue. In order to examine altered gene expression in tumour tissue it is an advantage to examine tumour and non-tumour tissue from the same individual fish; (3) To implement findings as diagnostic tools (biomarkers) for tumour formation in fish in marine environmental monitoring programs in order to identify possible sources of pollutants in marine environments.
Keywords
Fish;
Monitoring;
Genetic;
Flounder;
Flatfish;
Toxic substances;
Impacts;
Marine Region
76
Not associated to marine areas
0
Marine Region Map
