Acronym DigiBiotics
Category
Marine Biotechnology
Title Digital discovery of antimicrobial molecules from marine Arctic resources with reduced risk of triggering resistance Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator John Sigurd Mjøen Svendsen Coordinator email john-sigurd.svendsen@uit.no
Coordinator institution
UiT - The Arctic University of Norway (Norway)
Institutions involved
NA - Amicoat AS (Norway) ,
NA - AstraZeneca AB (Sweden) ,
UOA - University of Aberdeen (United Kingdom) ,
Start year 2017 End year 2023 Funding (€) € 2,097,055 Website https://www.digitallifenorway.org/research/digibiotics/ Summary The goal of DigiBiotics is to translate innovative scientific discoveries into commercially attractive propositions by combining in-depth scientific knowledge with a broad understanding of the requirements of successful drug discovery and development. This goal will be reached by fulfilling five scientific objectives and one training objective:
• Digitally mine genomes, isolate and identify novel antimicrobial molecules from Arctic marine microorganisms with a selection of compounds less prone to trigger resistance development
• Create, develop and validate experimental and computational methods for determination of molecular structure, absolute configuration and conformation.
• Provide, through new computational and experimental methods, an in-depth understanding of structure-activity relationships for “middle-space molecules” enabling optimization of their biological activity
• Compute quantitative structure activity relationships (QSAR) for knowledge-driven refinement of antimicrobial molecules into compounds with acceptable pharmacokinetics, optimizing potency, absorption, distribution and metabolic properties.
• Define the microbial targets and resistance development to provide feedback for refined design.
• Train young scientists in the cross-disciplinary skills needed for future successful drug discovery
Keywords
Bioprospecting;
Antimicrobials;
Genetic;
Human health;
Drug discovery;
Genomic;
Marine Region
76
Not associated to marine areas
0
Marine Region Map
