Acronym INBioPharm
Category
Marine Biotechnology
Title Integrated Novel Natural Product Discovery and Production Platform for Accelerated Biopharmaceutical Innovation from Microbial Biodiversity Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Alexander Wentzel Coordinator email NA
Coordinator institution
SINTEF - SINTEF (Norway)
Institutions involved
NA
Start year 2016 End year 2021 Funding (€) € 2,872,395 Website https://app.cristin.no/projects/show.jsf?id=563167 Summary Bioactive chemicals produced by microorganisms, like bacteria and fungi, isolated from nature have been the source of most antibiotics in medical use today. However, the fact that many antibiotics are currently losing their function due to the rapid spreading of antibiotic resistance among pathogenic bacteria and that coincidently only very few new antibiotics have reached the market the last decades, craves for an increased effort and new technology for the more rapid discovery of new bioactive compounds and their development into medical drugs to cure life-threatening bacterial infections in the future, as well as to treat other deadly diseases, including cancer.
The INBioPharm project will develop a new, generic technology platform for the more efficient discovery of novel bioactive compounds with improved prospects to become medical products. A unique national collection of marine microorganisms at SINTEF/NTNU will be used as the basis for the development of different new, complementary molecular biology, analytical and screening methods and their combination into one platform that can access and exploit the huge potential of microorganisms in nature to synthesize useful bioactive natural products in a more efficient way. Central to this effort will be the development of the actinobacterium Streptomyces coelicolor into a microbial cell factory that is capable of producing diverse bioactive compounds of other natural microorganisms, including the huge majority of bacteria that cannot be cultivated in the laboratory, and the large number of compounds of cultivable bacteria that are not produced under laboratory conditions.
Keywords
Bioactive compounds;
Bacteria;
Bioprospecting;
Human health;
Drug discovery;
Marine Region
76
Not associated to marine areas
0
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