Acronym MAPMAR
Category
Marine Biotechnology
Title Marine Plasmids Driving the Spread of Antibiotic Resistances Programme International Cooperation
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National-European Coordinator Fernando DE LA CRUZ Coordinator email NA
Coordinator institution
UC - University of Cantabria (Spain)
Institutions involved
KIT - Karlsruhe Institute of Technology (Germany) ,
NA - National Center for Mariculture (Israel) ,
Start year 2021 End year 2024 Funding (€) € NA Website https://www.era-learn.eu/network-information/networks/aquaticpollutants/1st-joint-call-2020/marine-plasmids-driving-the-spread-of-antibiotic-resistances Summary Antibiotic resistance genes (ARGs) are one of the most challenging contaminants of emerging concern (CECs). Instead of being directly produced by human activity, ARGs emerge as consequence of antibiotic use in clinical settings, and residual antibiotic contamination. ARGs spread through horizontal gene transfer and conjugative plasmids, because their ability to cross inter-species barriers, are key in this process. Recent findings revealed the existence of marine plasmids (MAPS) of global distribution and broad host range. These MAPS can transmit ARGs across oceanic distances, and may reintroduce them to human food chains via marine products. They are, however, different to classical plasmids from clinical settings. MAPMAR uses metagenomics, data science and single-cell sequencing to obtain a catalog of most prevalent and transmissible MAPs. By testing methods to block their transmission, MAPMAR explores strategies to curtail the risk of oceans acting as highways for ARG propagation.
Aims:
1. A catalog of the marine plasmidome, and its relationship to the plasmidome present in continental and estuarine ecosystems.
2. A list of the most transmissible MAPs identified in aquatic ecosystems, together with an assessment of their host range.
3. An assessment on the ability of MAPs and antibiotic resistant bacteria present in marine waters to re-enter into the AGR cycle by their incorporation to marine products. The ability of conjugation inhibitors to break this vicious cycle will be investigated.
Keywords
Antibacterial;
Metagenomic;
Marine Region
76
Not associated to marine areas
0
Marine Region Map
