Acronym NA
Category
Marine Biotechnology
Title Host-pathogen interactions: In vitro and in vivo exploration of the quorum sensing system of the marine fish pathogen Vibrio salmonicida Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Nils Peder Willassen Coordinator email nils-peder.willassen@uit.no
Coordinator institution
UiT - The Arctic University of Norway (Norway)
Institutions involved
NA
Start year 2006 End year 2009 Funding (€) € 625,600 Website https://prosjektbanken.forskningsradet.no/project/FORISS/174968 Summary The genus Vibrio is among the most numerous and ubiquitous of marine bacteria and commonly found as etiological agents of diseases in both vertebrates and invertebrates throughout the world. Vibrio salmonicida, a halophilic and psychrophilic (cold adapted ) marine gram-negative bacterium, the etiological agent of cold-water vibriosis (also called hemorrhagic syndrome or Hitra disease) in Atlantic salmon and cod, has been studied for some years. Still the molecular mechanisms of host invasion, host specificity, colonization and growth (host adaptation) are largely unknown. V. salmonicida probably combines several hitherto unknown factors to combat the immune defence of the host. The project will develop fundamental knowledge of intra-pathogenic and host-pathogen communication with V. salmonicida as a model of cold water vibrios. The knowledge enables us to apply genomic data extending from bioinformatics to functional analysis, and by this discover new targets for vaccines and pharmaceutical drugs, through network building, RNomics, structural analysis, together with state-of-the-art methods in functional genomics. By understanding the virulence factors possessed by V. salmonicida, we will be able to identify pathways of disease mechanisms useful for potential prevention and control of infections with cold water vibrios in future farming of marine fish species.
Keywords
Fish biology;
Disease;
Fish;
Genetic;
Salmon;
Bacteria;
Marine Region
76
Not associated to marine areas
0
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