Acronym NA
Category
Aquaculture
Title Host-virus interactions in Atlantic salmon Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Unni Grimholt Coordinator email unni.grimholt@veths.no
Coordinator institution
NVH - Norwegian School of Veterinary Science (Norway)
Institutions involved
NA
Start year 2008 End year 2011 Funding (€) € 1,191,612 Website https://prosjektbanken.forskningsradet.no/en/project/FORISS/183230?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=60&ProgAkt.3=FUGE-Funksjonell+genomforskn.i+Norg Summary Infectious pancreatic necrosis virus (IPNV) and infectious salmon anaemia virus (ISAV) are viruses causing threatening diseases in Norwegian aquaculture. Certainly, one of the most challenging problems in designing control strategies against these viruses is to define the specific factors, both in host and virus, required for virus replication and persistence. The overall goal of the project is to advance the understanding of antiviral defence mechanisms in salmon, the virulence mechanisms of the viruses, and host-virus interactions. The interferon (IFN) system of vertebrates plays a crucial role in the innate immune responses against virus infections. This project aims at advancing our understanding of the salmon IFN system by expression and activity studies of newly discovered IFNs as well as through functional studies of receptors and signalling proteins involved. Furthermore, studies of the cellular host immune responses, aimed at dissecting the presentation of viral antigens to T-cells, will be made possible by development of monoclonal antibodies and tetramer technology. The yeast-two hybrid system combined with pull-down experiments will be used to examine potential interactions between the IPNV proteins, the ISAV proteins and to map interactions between viral and host proteins. For both ISAV and IPNV development of recombinant viral systems will be continued representing optimal tools for studying the function of viral genes, including viral virulence factors, as well as enabling design of "safe" attenuated vaccines. Equally, will continued studies of MHC peptide antigen presentation provide knowledge about viral epitopes optimal for inactivated and recombinant viral vaccines. RNA interference, including optimisation for use in salmonid cells, will be implemented in the functional studies.
Keywords
Genetic;
Engineering;
Vaccines development;
Protein;
Disease;
Fish;
Salmon;
Marine Region
76
Not associated to marine areas
0
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