Acronym NA
Category
Marine Biotechnology
Title How do the winter ulcer pathogens control its environment? Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Nils Peder Willassen Coordinator email NA
Coordinator institution
UiT - The Arctic University of Norway (Norway)
Institutions involved
NA
Start year 2012 End year 2017 Funding (€) € 490,300 Website https://prosjektbanken.forskningsradet.no/en/project/FORISS/214374?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=420&Organisasjon.3=UNIVERSITETET%20I%20TROMS%C3%98%20-%20NORGES%20ARKTISKE%20UNIVERSITET&source=FORISS&projectId=213692 Summary Winter ulcer disease is one of the main bacterial infectious diseases of concern in the Norwegian fish farming industry, since management procedures and vaccination strategies remain inadequate. Direct losses, down-classification due to low quality and reduced production volume amount to significant economic losses. Fish with winter ulcer disease suffers from severe ulceration and internal pathology for months, giving great animal welfare concern and negative consumer attitudes. Moritella viscosa is considered the main causative agent of the disease and all farmed Atlantic salmon are today vaccinated with M. viscosa components. Aliivibrio wodanis are recurrently isolated together with M. viscosa may indicate that there exists an interspecific bacterial communication between these species, or otherwise be beneficial to A. wodanis as a secondary pathogen during the development of the disease. How A. wodanis can exploit the impairment of normal host functions under disease development, influence pathogenicity or e.g. suppress the healing process of skin ulcers is not known. Based on the status of knowledge we have formulated the following hypothesis: the winter ulcer pathogens are able to communicate and control their merged systems to regulate their metabolome and proteome in order to control its environment, to prevent other bacteria to infect the host and at the same time become a more efficient infection agent. The main goal of the projects is to address the lack of knowledge regarding cell-to-cell communication in development of winter ulcer by identifying systems and effector molecules involved in cell-to-cell communication between M. viscosa and A. wodanis and the relevance of such systems/effector molecules in controlling the environment in order to develop winter ulcer. Practically, this study aims to understand the interplay between the two bacteria, and, if and how A. wodanis can influence the pathogenic behavior of M. viscosa or e.g. suppress the healing process of skin ulcers. To achieve our goals, genes involved in cell-cell communication has been inactivated and their contribution to disease development explored. The interplay between bacteria has been analyzed using omics techniques after in cultivation of the bacteria under different conditions. The knowledge derived from the project will be incorporated into vaccine formulations, vaccination techniques, and management strategies related to vaccination against winter ulcer disease.
Keywords
Vaccines development;
Fish;
Salmon;
Bacteria;
Engineering;
Genomic sequencing;
Disease;
Marine Region
76
Not associated to marine areas
0
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