Acronym InNoVacc
Category
Aquaculture
Title Indo-Norway platform for developing candidate vaccines to invertebrate, piscine and avian species Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Espen Rimstad Coordinator email espen.rimstad@numbu.no
Coordinator institution
NMBU - Norwegian University of Life Sciences (Norway)
Institutions involved
NA
Start year 2008 End year 2013 Funding (€) € 3,927,849 Website https://prosjektbanken.forskningsradet.no/en/project/FORISS/183196?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=0&Organisasjon.3=NORGES+VETERIN%C3%86RH%C3%98GSKOLE Summary On the Norwegian side in InNoVacc we have focused on experimental immunization and load tests with pancreas disease virus ( SAV ) , ISA virus and testing of various adjuvants ( CpG , polyI : C ) and vector vaccines to get a good stimulation of the innate immune response , and minimizing side effects in salmon. We have worked to make viral vaccines for fish more effective by measuring the expression of genes related to immune response. Characterization of the virus that causes heart and skeletal muscle inflammation , Piscint reovirus ( PRV ) has been a work that has been added. We have worked to develop the replication machinery of SAV for use as a vector to introduce the vaccine antigens in fish, and this has been very successful for use against the ISA and will be tested for several other viruses. We have characterized regulatory proteins of the ISA virus carrying the virus proteins into and out of the nucleus , and found the ISA virus protein that counteracts cellular RNA interference. We have identified and characterized dendritic cells ( DC) in Atlantic salmon . These are cells which are known as professional antigen presenting cells, thus of considerable potential importance for the efficacy of vaccines. There have been efforts to describe IgT , one immunoglobulin in fish seems to have special significance for mucosal surfaces. Furthermore, the mucous membranes in the intestines of salmon were morphologically characterized and accumulation of lymphoid cells in the gills of salmon has been described in more detail.. On the Indian side has immune stimulation against White spot disease virus ( WSSV ) in shrimp been central. Shrimps lack an acquired immune response and therefore is not a classical vaccination in which one first induces an immune response using viral antigens , and then this response is memorized and revived and enhanced when the animal comes into contact with the relevant virus. Shrimp do not have this ability to " remember" the antigen. Methods have therefore been providing shrimp antigens that remain on mucosal surfaces is the gateway for WSSV thus compete with viruses for admission into cells and / or stimulate the innate immune response of shrimp so they will be generally better equipped to withstand against a viral infection . During this work we found several similarities between the immune response in shrimp and salmon and become aware that it is not always beneficial to use mammalian immunology as a template for the salmon's response. Aquaculture is an explicit priority in India, both domestic food production and export product (shrimp ). There are many similarities with the Norwegian salmon farming in terms of the degree of industrialization, the need for biosecurity measures , controlling the movement of live animals , quality of intake water , production of pathogen- fry. Norway have much to contribute in research , technology , equipment , disease control , disease control, and management . Good knowledge and confidence is a prerequisite for achieving such cooperation to work.
Keywords
Shrimp;
Crustacean;
Salmon;
Genetic;
Engineering;
Disease;
Vaccines development;
Fish;
Shellfish;
Marine Region
76
Not associated to marine areas
0
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