Acronym NA
Category
Aquaculture
Title Is Amoebic Gill Disease in salmon a hyper-reactive inflammatory response? Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Øystein Evensen Coordinator email NA
Coordinator institution
NMBU - Norwegian University of Life Sciences (Norway)
Institutions involved
NA
Start year 2015 End year 2017 Funding (€) € 33,185 Website https://prosjektbanken.forskningsradet.no/project/FORISS/244542?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=4170&TemaEmne.1=LTP2%20Fornyelse%20i%20offentlig%20sektor Summary Infection with Neoparamoeba perurans causes amoebic gill disease. It is understood that clinical signs and mortality depend on the level of infection and subsequent severity of the gill pathology. Therefore low or early infections may remain unnoticed. Mo rtalities are typically in the range of 10-20% but higher losses up to 70% have been reported. Chronic cases are also seen. While AGD has been known for many years the mechanisms inducing the inflammatory and hyperplastic responses are not understood in detail. What tips the balance from a non-reactive profile towards a reactive variant (with proliferation) is a key question.
Our proposal is to test (preliminary) a hypothesis that AGD is a hyper-reactive inflammatory disease of the gills and we draw paral lels to similar conditions of lung inflammation in mammals (like asthma). The clinical manifestation is reliant on the severity of the inflammatory response where cytokine profiles and chemokines fingerprints are crucial for the balance. And more, we propose that the gill microbiota is the key element in balancing the response where the microbiota impacts the status of intraepithelial immune organ, which has a major regulatory function of the immune responses of the gills.
Keywords
Disease;
Fish;
Salmon;
Fish health;
Marine Region
76
Not associated to marine areas
0
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