Acronym NUTREPIFISH
Category
Marine Biotechnology
Title Epigenetic and transcriptional effects of optimizing 1-C nutrients to improve healthy growth in Atlantic salmon Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Kaja Helvik Skjærven Coordinator email NA
Coordinator institution
IMR - Institute of Marine Research (Norway)
Institutions involved
NA
Start year 2017 End year 2021 Funding (€) € 843,037 Website https://prosjektbanken.forskningsradet.no/project/FORISS/267787?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=150&ProgAkt.3=HAVBRUK2-Stort+program+for+havbruksforskning Summary Increasing the health quality represents a potential for reducing the high mortality in Atlantic salmon production. Nutritional DNA methylation changes can lead to irreversible life-long phenotypic effects, and development represents a sensitive period for the establishment of improved health quality through new DNA methylation patterns. The 1-C nutrients, methionine, folate, vitamin B6 and B12, are responsible for the transfer of the methyl group to DNA and thereby directly influence the epigenetic regulation of gene expression. The hypothesis of this project is that the composition of 1-C nutrients affects the gene expression patterns for healthy growth (increased growth / immune capacity, and decreased fat accumulation) through epigenetic mechanisms, particularly DNA methylation. The aim is to increase the potential for healthy growth in early life stages by optimizing the dietary-induced epigenetic regulation of gene expression. This will be achieved through improved 1-C nutrient composition in a) gonads, b) eggs and c) smoltification. This will be reached by linking metabolomics, transcriptomics and epigenomics with traditional growth and histological studies for in depth studies of nutritional composition of parental feed, yolk sac nutrients or smoltification feed that sets the future potential for healthy growth. This is in line with the needs for aquaculture which is knowledge on how micronutrient availability adjusts the potential for healthy growth and reduces fat accumulation through epigenetic regulation of gene expression as recently shown by us, using zebrafish as a model.
Keywords
Fish biology;
Genetic;
Fish;
Diets;
Salmon;
Fish health;
Marine Region
76
Not associated to marine areas
0
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