Acronym NA
Category
Aquaculture
Title The road to successful DNA vaccination of Atlantic salmon against virus diseases Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Børre Robertsen Coordinator email borre.robertsen@uit.no
Coordinator institution
UiT - The Arctic University of Norway (Norway)
Institutions involved
NA
Start year 2016 End year 2018 Funding (€) € 360,000 Website https://prosjektbanken.forskningsradet.no/project/FORISS/254907?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=180&ProgAkt.3=HAVBRUK2-Stort%20program%20for%20havbruksforskning&source=FORISS&projectId=269015 Summary Farmed Atlantic salmon is attacked by several pathogenic viruses, which represent a continuous threat for the aquaculture industry. Vaccines based on inactivated virus are available for some diseases like PD, but do not give satisfactory protection. Vaccines against the viruses causing heart skeletal and muscle inflammation and cardiomyopathy syndrome are not available because the viruses cannot yet be grown in cell culture. Our group is working on DNA vaccines because they are independent of virus culture and because they give a very high level of protection of salmonids against rhabdovirus infection. While DNA vaccines against other salmon viruses have previously shown rather modest protection, our group has recently shown that a very high level of protection can be obtained with a DNA-vaccine against infectious salmon anemia virus (ISAV) using interferon (IFN) as an adjuvant. A DNA-vaccine is a plasmid expressing the surface protein of the virus, which is injected into the fish muscle. A plasmid expressing IFN is co-injected as adjuvant. IFN is a protein that has a critical role in immunity against viruses. Our recent work suggests that the properties of the virus antigen are very important for the effect of IFN as adjuvant. In this project we are going to study more closely the role of IFN in DNA vaccination against PD-virus and the molecular signature of immune genes induced by the DNA vaccine against PD. We are also going to investigate how subcellular location of virus protein antigens influences the immune response of DNA vaccines. The overall goal is to develop a concept for DNA vaccines that works well against a broad spectrum of salmon viruses.
Keywords
Vaccines development;
Fish health;
Disease;
Salmon;
Fish;
Marine Region
76
Not associated to marine areas
0
Marine Region Map
