Acronym SALMOCARD
Category
Marine Biotechnology
Title Characterization, prediction and reduction of cardiomyopathy syndrome (CMS) in Atlantic salmon Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Ida Beitnes Johansen Coordinator email ida.johansen@nmbu.no
Coordinator institution
NMBU - Norwegian University of Life Sciences (Norway)
Institutions involved
NA - Aqua Competence AS (Norway) ,
NA - PHARMAQ Analytiq AS
(Norway) ,
UiO - University of Oslo (Norway) ,
Start year 2021 End year 2023 Funding (€) € 981,835 Website https://www.fhf.no/prosjekter/prosjektbasen/901672/ Summary Cardiomyopathy syndrome (CMS) is a serious heart disease in Atlantic salmon ( Salmo salar). During the last decade, it has become one of the most important causes of illness and mortality in the Norwegian farming industry. Understanding the pathophysiology underlying this disease as well as new, accurate diagnostic tools to assess mortality risk is therefore in high demand by the aquaculture industry. Despite significant research efforts in recent decades, there are large knowledge gaps in our understanding of the pathogenesis underlying CMS. In particular, the understanding of interactions between the salmon's physiology and immune response in the development of the disease and the severity of the disease is poorly understood. Although the disease is triggered by piscine myocarditis virus (PMCV), PMCV infection does not necessarily lead to clinical CMS. Therefore, knowledge of how and why PMCV induces CMS in some individuals but not in others, crucial for solving the disease problem and for developing preventive tools. The project will work according to the hypothesis that individual variation in stress and immune responsivity (immune-neuroendocrine phenotype) can explain the variation in vulnerability to CMS.
Performance target:
1. To identify immune-neuroendocrine phenotypes (INPs) of salmon vulnerable to developing CMS.
2. To investigate whether the development of CMS is due to virus-induced damage or immune pathology in the host.
3. To develop reliable biomarkers of CMS-related mortality risk.
Keywords
Fish;
Disease;
Salmon;
Diagnostic application;
Marine Region
76
Not associated to marine areas
0
Marine Region Map
