Acronym NA
Category
Marine Biotechnology
Title Vaccination against intracellular bacterial pathogens for aquaculture. Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Hanne C. Winther-Larsen Coordinator email hannewi@farmasi.uio.no
Coordinator institution
UiO - University of Oslo (Norway)
Institutions involved
NA
Start year 2014 End year 2017 Funding (€) € 957,000 Website https://prosjektbanken.forskningsradet.no/en/project/FORISS/233849?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=270&TemaEmne.2=Marin+bioteknologi&source=FORISS&projectId=303149 Summary The project will investigate newly discovered vaccine candidates (VC) against infections by two intracellular bacterial pathogens causing major problems in aquaculture, namely Piscirickettsia salmonis and Francisella noatunensis. F. noatunensis sp is one of the main factors hampering the development of fish farming based on Atlantic cod in Norway and is deleterious in tilapia, a fish that is cultured by over 3.5 mill tons/year world wide. P. salmonis infections have been devastating to culturing of salmon ids in Chile. As of today no effective treatments are available against the diseases. One of our VCs has already been tested effective in our newly established Zebrafish infection model system and is ready for vaccine trial experiments in cod. The two oth er candidates need further isolation and characterization before it can be tested in salmonids and tilapia. If the VCs cause immunity in the fish species in question it will have huge market potential for fish vaccine production in which Norway is world leading. Moreover, the vaccines will improve the health of the fish and will greatly impact the outcome from the fish farming industry based on cod, salmonids and tilapia. The intracellular nature of Francisella and Piscirickettsia have up until now compli cated the development of protective measures much unlike efficient vaccines against important extracellular bacterial infections in salmon based on whole inactivated bacteria injected with oil adjuvants. Live attenuated vaccines, most easily established by genetically modification, have proved the most efficient against intracellular pathogens. However, the used of GMO for vaccines purposes are highly regulated and restricted. The new non-GMO based discovery described in this project aim to solve this problem.
Keywords
Engineering;
Bacteria;
Vaccines development;
Cod;
Fish;
Genetic;
Marine Region
76
Not associated to marine areas
0
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