Acronym NA
Category
Marine Biotechnology
Title Exploiting and conserving deep-sea genetic resources Programme Nat. Programme (supported by ESIF)
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National-European Coordinator NA Coordinator email NA
Coordinator institution
NUI - National University of Ireland (Ireland)
Institutions involved
MI - Marine Institute (Ireland) ,
Start year 2016 End year 2021 Funding (€) € 1,940,150 Website http://marinescience.ie/summary-sfi-project-exploiting-and-conserving-deep-sea-genetic-resources/ Summary We aim to elucidate novel natural products from sponges and corals in Ireland’s offshore waters and increase knowledge of their economic value and distribution. Deep-water areas are rich in these diverse taxa which are known to have a high prevalence of bioactivity. The deep-sea has massive promise for biodiscovery work with very high hit rates, probably because extreme environmental conditions promote the evolution of unique secondary metabolites. We outline a sampling and screening programme seeking extracts which display both a dose response and minimal cytotoxicity to healthy cell lines. We will use 1H NMR and LC/MS profiling to dereplicate known metabolites. We will conduct iterative fractionations to produce purified natural products and subject these to spectroscopic analysis (1- and 2-dimensional NMR spectroscopy, HR-ESIMS, IR, UV and, when appropriate, CD and/or X-ray) to determine their structures. Once metabolites are characterized, biological assays will be conducted to produce lead molecules with determined pharmacological potential. To increase the efficiency of future sampling, we will produce statistical inference models to determine the likelihood of any given species producing a ‘hit’. Applying this information to species distribution modeling, we will produce predictive maps of biodiscovery potential to maximize the economic impact of future biodiscovery work.
Keywords
Corals;
Drug discovery;
Sponge;
Bioprospecting;
Bioactive compounds;
Human health;
Marine Region
76
Not associated to marine areas
0
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