Acronym NA
Category
Aquaculture
Title Viral myocarditis and regenerative mechanisms of the salmon heart Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Øystein Evensen Coordinator email NA
Coordinator institution
NMBU - Norwegian University of Life Sciences (Norway)
Institutions involved
NA
Start year 2017 End year 2021 Funding (€) € 701,570 Website https://prosjektbanken.forskningsradet.no/project/FORISS/267807?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=0&Organisasjon.5=Institutt+for+basalfag+og+akvamedisin Summary Piscine myocarditis virus (PMCV) is the first member of Totivirdae that infects a vertebrate host, causing cardiomyopathy syndrome (CMS). The salmon heart has a good ability to regenerate from virus-induced damage after HSMI and PD disease, but for CMS there are few signs of regeneration and scarring and rupture is the ultimate consequence. The question is why a PMCV infection a 'kiss of death' while PRV and SAV infections are not? If the heart lesions causing HSMI and PD are of a character and degree that enables regeneration, why is regeneration impaired or blocked in CMS affected hearts? Our approach to this is to study the mechanisms of cardiomyocyte regeneration or inhibition of these after infection of the three viruses. We hypothesize that PMCV infection results in production of a protein toxic to the infected myocytes and this protein remains in the cardiomyocytes as aggregates. The damage caused to the cardiomyocytes is so severe that regeneration is impossible while for SAV (PD) and PRV (HSMI) infection damage is reversible and regeneration occurs. Better knowledge of underlying mechanisms will facilitate better intervention and optimization of management based routines, ie risk management. As part of this we will also explore the potential of non-invasive methods for early diagnosis of viral myocarditis from sequential sampling of serum from salmon experimentally infected with SAV, PRV or PMCV. Highly sensitive reporter cell lines will be used to assess inflammatory responses to infection and tissue damage. This project will fill knowledge gaps related to the viral agent causing CMS. The results will open up for disease limiting measures as therapy and vaccination.
Keywords
Fish;
Salmon;
Diagnostic application;
Fish health;
Disease;
Marine Region
76
Not associated to marine areas
0
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