Acronym InNOVacc-II
Category
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Title Indo-Norwegian project for the development of candidate vaccines for fish Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
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Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
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Specific Programme (FP7)
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Funding source National Coordinator Espen Rimstad Coordinator email espen.rimstad@nmbu.no
Coordinator institution
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Institutions involved
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Start year 2015 End year 2017 Funding (€) € 315,789 Website https://www.nmbu.no/fakultet/vet/institutter/paraklinisk/forskning/prosjekter/node/22017 Summary This project continues certain activities from the preceding Norwegian-Indian project InNoVacc. The project will contribute to the development of antigens that may have the potential to be included in vaccines, and morphological characterization of nodavirus infections in tropical seabass. Those active in this project will mainly be exchange PhD students who are in shorter stays in Norway.
The project includes three work packages. In work package 1 lipid-modified virus antigens will be developed for expression in bacteria. Bacterial lipoproteins have high antigenicity because of the adjuvant properties of the added lipids. By modification of proteins with lipids the possibility that a protein antigen may induce an adaptive immune response will increase, and thereby increase antibody production. The project aims to lipid-modifying proteins from piscine orthoreovirus, salmonid alphavirus and nodavirus from seabass. Two proteins from piscine orthoreovirus have been cloned and are currently examined whether the lipid modification was successful. One aims to clone and express proteins from SAV and nodavirus in the near future.
In work package 2 will capsid proteins from seabass nodavirus be expressed in a system based on the machinery of salmonid alphavirus. If antigens from work package 1 and 2 function satisfactorily in the laboratory they will be tested in immunization ? exposure experiment.
In work package 3 the immunological and morphological responses as well as gene expression in gills and intestines in fish after nodavirus infection will be characterized. Students from India are scheduled to perform this work in Norway using material from infection experiments conducted in India.
Keywords
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Marine Region
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