Acronym SaliVax
Category
Aquaculture
Title DNA vaccine directed against salmon lice saliva Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Aina-Cathrine Øvergård Coordinator email Aina-Cathrine.Overgard@uib.no
Coordinator institution
UiB - University of Bergen (Norway)
Institutions involved
NA
Start year 2022 End year 2025 Funding (€) € 700,000 Website https://www.fhf.no/prosjekter/prosjektbasen/901760/ Summary Salmon lice cause a number of disease and welfare challenges as a result of an intensive lice treatment regime, and are an obstacle to further growth in the industry. A measure that can provide a significant improvement in relation to the current welfare situation is a salmon lice vaccine. The most promising vaccine candidates that have been tested so far have been based on the fact that antibodies work or are taken up via the louse's gut. However, this has not led to the development of a commercial vaccine, as the antibodies from the salmon are probably quickly degraded by digestive enzymes in the louse's gut. This project will thus see whether proteins that work at the interface between the louse and the salmon can have greater potential as vaccine antigens.
Goals:
• To investigate whether proteins that are important in the interaction between salmon lice and salmon (the parasite-host interaction) can be used in a salmon lice vaccine, by trying to clarify whether salmon have an inherent resistance mechanism that is dampened by components in the salmon lice's secretions, and if it is possible to inhibit this so that the salmon itself activates the necessary immune responses against the salmon lice.
• To look more generally at the possibilities of increasing mucosal levels of antibodies using DNA vaccines, where one can make use of different plasmid designs, molecular adjuvants and administration methods to achieve this.
Keywords
Genetic;
Salmon;
Engineering;
Parasite;
Fish;
Fish health;
Vaccines development;
Marine Region
76
Not associated to marine areas
0
Marine Region Map
