Acronym NA
Category
Aquaculture
Title Infektuøs lakseanemi virus: Molekylær epidemiologi og karakterisering av virusets glykoproteiner - Infectious salmon anemia virus: Molecular epidemiology and characterization of the virus' glycoproteins Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Knut Falk Coordinator email knut.falk@vetinst.no
Coordinator institution
NVI - Norwegian Veterinary Institute (Norway)
Institutions involved
NA
Start year 2002 End year 2005 Funding (€) € 417,803 Website https://www.fhf.no/prosjekter/prosjektbasen/552132/ Summary Infections caused by infectious salmon anemia virus lead to one of the most deadly diseases the Norwegian aquaculture industry is struggling with. The virus and the disease have been detected in Scotland, Canada, the USA, the Faroe Islands, Chile in addition to Norway. This means that countries that have salmon farming as an important source of food and income must make further efforts to bring this disease and the virus that causes it under control. With this project a genotyping system was established including testing on field material. The structural proteins of the ISA virus were identified and characterized.
Variation was found for the phenotypic characteristics of the virus that may be important for understanding virulence and pathogenesis.
Viruses were typed using monoclonal antibodies and nine serogroups were identified. Tentatively, three possible neutralizing epitopes on the HE protein were also identified.
Coals:
1) To practically establish genotyping based on the HE gene and the gp50 (f) gene, as well as evaluate this type system for practical use in connection with disease detection and diagnostic studies. Furthermore, supplement the phylogeny of ISA virus by trying to include more sequence information from old ISA outbreaks.
2) To identify and characterize the structural proteins of the virus with the main emphasis on surface glycoproteins.
3) To characterize the ISA virus phenotypically with a view to identifying virulence factors and markers.
Keywords
Protein;
Engineering;
Fish;
Genetic;
Salmon;
Genomic sequencing;
Disease;
Marine Region
76
Not associated to marine areas
0
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