Acronym NA
Category
Aquaculture
Title Basic studies of epithelial responses in the context of gill proliferative disease in Atlantic salmon Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Mona Gjessing Coordinator email NA
Coordinator institution
NVI - Norwegian Veterinary Institute (Norway)
Institutions involved
NA
Start year 2014 End year 2017 Funding (€) € 227,270 Website https://prosjektbanken.forskningsradet.no/en/project/FORISS/234037?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=30&ProgAkt.3=HAVBRUKS-Havbruk+-+en+n%C3%A6ring+i+vekst Summary Proliferative gill diseases (PGDs) is a major challenge in Atlantic salmon farming. Many microorganisms have been found in diseased gills. The main host response is an overgrowth of the gill surface cells to an extent that cause respiratory difficulties. In other words an important part of the disease problem in PGDs is an inappropriate host response. Research efforts have so far focused on detection of microorganisms and description of disease changes. The main objective of this project is to increase th e understanding of the surface cell host response in PGDs. A laboratory model with the cells in question will be established and characterized. Different growth stimuli and signals suspected to cause the overgrowth will be characterized and tested, also with regard to inhibition. This may open up new therapeutic possibilities for modulation of host response to avoid the respiratory difficulties by surface cell overgrowth. The focus is on the basic mechanisms leading to the observed cell overgrowth. Severa l microorganisms associated with PGD have not been isolated in pure culture. This is an important prerequisite for controlled challenge experiments to test the importance of the microorganisms for disease. A subgoal of the project is thus to explore if th e establishment of a cell culture as above also can be used to isolate microorganisms which have not been possible to cultivate so far.
Keywords
Disease;
Fish;
Salmon;
Fish health;
Marine Region
76
Not associated to marine areas
0
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