Acronym FATTYBONE
Category
Aquaculture
Title Dietary fatty acids as modulators of bone metabolism in gilthead sea bream (Sparus aurata) Programme Nat. Programme (supported by ESIF)
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National-European Coordinator Jorge Dias Coordinator email jorgedias@sparos.pt
Coordinator institution
CCMAR - Center of Marine Sciences (Portugal)
Institutions involved
FCT - Foundation for Science and Technology (Portugal) ,
Start year 2008 End year 2011 Funding (€) € 191,453 Website https://www.fct.pt/apoios/projectos/consulta/vglobal_projecto?idProjecto=70855&idElemConcurso=860 Summary Presently, the replacement of significant amounts of marine fish oil by vegetable oils is a major trend in the aquaculture feed industry. Emerging evidence from human and terrestrial vertebrate studies supports the hypothesis that dietary lipids play an important role in skeletal biology and bone health. Knowledge on the mechanisms underlying the nutritional regulation of bone metabolism is extremely scarce in fish. In this project, we speculate that changes in the dietary ratio of n-6:n-3 fatty acids may also modulate tissue eicosanoids production, namely PGE2 and affect bone formation and mineralization in growing fish.
The main objective of the project was to characterize and elucidate the role of dietary fatty acids and other nutritional factors associated to low-fishmeal and fish oil formulations as modulators of bone metabolism in gilthead seabream, the major species for aquaculture in the Mediterranean region. To attain this general objective, the specific targets were to generate new data on: (1) The role of fish-derived serum and single fatty acids on bone mineralizing parameters by means of an in vitro approach with seabream bone derived cell lines; (2) The effect of graded levels of dietary DHA, dietary phytase supplementation doses and various dietary lipid sources on the fatty acid and mineral composition of vertebral bone and relate such changes to bone protein matrix growth and mineralization capacity, examined by biochemical, histochemical and molecular approaches. At the start of the project, there was no information regarding how the general trend for replacing fishmeal and fish oil by vegetable ingredients in fish feeds and concomitant changes in the dietary ratio of n-6:n-3 fatty acids affected bone protein matrix growth and mineralization in growing fish. The project intended to contribute towards a better understanding of the mechanisms underlying the nutritional regulation of bone metabolism in fish.
Keywords
Diets;
Fish biology;
Fish oil replacement;
Feed composition;
Fish;
Seabream;
Marine Region
76
Not associated to marine areas
0
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