Acronym GP3
Category
Aquaculture
Title Genomic epidemiology and Phage-based Prevention of salmon associated Pasteurella Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National Coordinator Thomas Sicheritz-Pontén Coordinator email thomassp@sund.ku.dk
Coordinator institution
KU - University of Copenhagen (Denmark)
Institutions involved
NA - ACD Pharma (Norway) ,
NA - Lerøy Norway Seafoods AS (Norway) ,
NA - MOWI ASA (Norway) ,
NA - PHARMAQ Analytiq AS
(Norway) ,
NA - STIM AS (Norway) ,
NA - University of Leicester (United Kingdom) ,
UoS - University of Stirling (United Kingdom) ,
Start year 2021 End year 2025 Funding (€) € 942,085 Website https://www.fhf.no/prosjekter/prosjektbasen/901707/ Summary Pasteurella , the causative agent of pasteurellosis, is an increasingly emerging threat for farmed Norwegian salmon, and despite its implications and impact on fish stocks, little is known about this infectious agent. Antibiotic treatments are generally discouraged, vaccine development is still in its infancy and no specific effective treatments currently exist. An obvious, targeted and timely approach to remove Pasteurella from salmon is to utilize bacteriophages the natural predators of bacteria. Bacteriophages, or phages for short, are viruses that specifically infect and kill bacteria without infecting, or further impacting animal cells. They can be applied to the water directly to kill bacteria and can be thought of as a unique 'live' antibacterial, to bridge the line between antibiotics and vaccines, making antimicrobial therapy more targeted and preventing problems associated with antibiotic resistance. Unlike vaccines, phages can both remove disease from fish and reduce disease spread within the wider environment, lowering the chances for wild fish to be infected.
Main objective:
To develop a targeted phage therapy solution to prevent and control Pasteurella skyensis and other strains associated with pasteurellosis in Atlantic salmon farms.
Sub-objectives:
• To identify the diversity and distribution of Pasteurella in both Norwegian and Scottish farmed salmon.
• To identify and isolate phages that attack and kill salmon associated Pasteurella strains.
• To determine the safety, efficacy and formulation for these phages.
• To produce safety documentation according to the Norwegian Food Authority (NoFA) requirements so that real-life field trials can be allowed. Field trials will be carried out to develop easy-to-use administration methods and provide efficacy documentation for the use of phage-based solutions against Pasteurella.
Keywords
Antimicrobials;
Disease;
Genomic sequencing;
Fish health;
Fish;
Bacteria;
Salmon;
Marine Region
13
Northern North Sea (27.IVa)
44
Spitzbergen and Bear Island (27.IIb)
41
Norwegian Sea (27.IIa)
3
Marine Region Map
