Acronym 3DLife
Category
Marine Biotechnology
Title Emulating life in 3D with digital and experimental tissue models Programme National Programme
Instrument (FP6)
Contact Type (FP7)
Strand (Interreg)
NA
Theme (FP7)
Activity Area (FP6)
Regional Area (Interreg)
Action (COST)
NA
Specific Programme (FP7)
NA
Funding source National
Coordinator institution
NTNU - Norwegian University of Science and Technology (Norway)
Institutions involved
SINTEF - SINTEF (Norway) ,
Start year 2017 End year 2022 Funding (€) € 2,167,220 Website https://prosjektbanken.forskningsradet.no/en/project/FORISS/269273?Kilde=FORISS&distribution=Ar&chart=bar&calcType=funding&Sprak=no&sortBy=date&sortOrder=desc&resultCount=30&offset=30&TemaEmne.2=Generisk+biotek+metodeutvikling Summary 3DLife aims to develop novel strategies for microtissue engineering in 3D, to provide model systems of organ function and bridge the gap to in vivo conditions. To understand how the microenvironment affects cells we will synthesize novel and tuneable extracellular scaffold materials, and develop tools for high-throughput screening (HTS) of 3D cell cultures to assess genetic expression patterns in response to defined scaffold properties. These advances have limited translational potential without a digital approach that can process the vast data output from HTS analyses and provide a systems-level understanding of material-cell interactions. By applying a computational model, we can predict the requirements of organotypic cells to their microenvironment and tailor materials for improved in vivo-like tissue and organ models for research and clinical applications beyond the state of the art. To achieve this ambitious goal, 3DLife brings in expert competence within material engineering, high-throughput analyses, transcriptomics and bioinformatics, cell biology and cultivation, microsystem technology and mathematical and computational modelling from NTNU and SINTEF supported by international academic collaboration. The project will contribute to the Centre for Digital Life Norway (DLN) with new knowledge, materials and methodology with a broad field of application in biotechnology.
Keywords
Technology;
Algae;
Biomaterial;
Bioprospecting;
Biology;
Genetic;
Marine Region
76
Not associated to marine areas
0
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